Redox Regulation of Store-Operated Ca2+ Entry
نویسندگان
چکیده
منابع مشابه
Regulation of Store-Operated Ca2+ Entry by Septins
The mechanism of store-operated Ca2+ entry (SOCE) brings extracellular Ca2+ into cells after depletion of intracellular Ca2+ stores. Regulation of Ca2+ homeostasis by SOCE helps control various intracellular signaling functions in both non-excitable and excitable cells. Whereas essential components of the SOCE pathway are well characterized, molecular mechanisms underlying regulation of this pa...
متن کاملRegulation of store-operated Ca2+ entry during the cell cycle.
Cytoplasmic Ca(2+) signals are central to numerous cell physiological processes, including cellular proliferation. Historically, much of the research effort in this area has focused on the role of Ca(2+) signals in cell-cycle progression. It is becoming clear, however, that the relationship between Ca(2+) signaling and the cell cycle is a 'two-way street'. Specifically, Ca(2+)-signaling pathway...
متن کاملCa2+ influx and the store-operated Ca2+ entry pathway undergo regulation during mouse oocyte maturation
In preparation for fertilization, mammalian oocytes undergo optimization of the mechanisms that regulate calcium homeostasis. Among these changes is the increase in the content of the Ca(2+) stores ([Ca(2+)]ER), a process that requires Ca(2+) influx. Nevertheless, the mechanism(s) that mediates this influx remains obscure, although is known that [Ca(2+)]ER can regulate Ca(2+) influx via store-o...
متن کاملModulation of store-operated Ca2+ entry by cyclic-ADP-ribose.
Store-operated Ca2+ entry plays an important role in Ca2+ homeostasis in cells but the mechanisms of control of these channels are not completely understood. We describe an investigation of the role of the CD38-cyclic-ADP-ribose (cADPR)-ryanodine-channel (RyR) signaling pathway in store-operated Ca2+ entry in human smooth muscle. We observed that human myometrial cells have a functional store-o...
متن کاملSTIM2 drives Ca2+ oscillations through store-operated Ca2+ entry caused by mild store depletion.
Abstract Agonist-induced Ca(2+) oscillations in many cell types are triggered by Ca(2+) release from intracellular stores and driven by store-operated Ca(2+) entry. Stromal cell-interaction molecule (STIM) 1 and STIM2 serve as endoplasmic reticulum Ca(2+) sensors that, upon store depletion, activate Ca(2+) release-activated Ca(2+) channels (Orai1-3, CRACM1-3) in the plasma membrane. However, t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Antioxidants & Redox Signaling
سال: 2014
ISSN: 1523-0864,1557-7716
DOI: 10.1089/ars.2013.5615